“Dr. Grupp serves as Chief of the Cellular Therapy and Transplant Section, Director of the Cancer Immunotherapy Program, and Director of Translational Research in the Center for Childhood Cancer Research at CHOP, and the Novotny Professor of Pediatrics at the University of Pennsylvania Perelman School of Medicine. A BMT physician, he is a member of the Division of Oncology and the Medical Director of the Cell and Gene Therapy Lab.
Dr. Grupp’s primary laboratory interest is developing novel cell therapies for pediatric cancers. His clinical research focuses on the use of CAR T and other engineered cell therapies in relapsed cancers. He led all of the pediatric ALL trials of CTL019 (now approved as Kymriah), including the largest, most successful engineered T cell therapy clinical trial conducted to date, as well as the global registration trial for CTL019. He presented the Clinical Perspective at the July 2018 FDA ODAC meeting, at which reviewers voted 10-0 recommending approval for Kymriah in pediatric ALL.”